A Review Of arthritis rheumatoide

In the world, more and more and more people suffer from the inability of their immune systems to differentiate between healthy cells or invaders microscopic organisms. Organs and tissues are being attacked by defenses against disease that they once had.




International research efforts are being made to fight this trend - such as an initiative in London's Francis Crick Institute, where two world experts, James Lee and Carola Vinuesa have established distinct research groups to determine the exact nature of the autoimmune disorder in the way that these diseases are well-known.


Lee stated to the Observer, that autoimmune cases increased in the west in the past 40 years. But, some of these cases are now occurring in countries that have not suffered from the disease.


For instance, the Middle East and East Asia are the regions with the highest number of cases of inflammatory intestinal disease. They had never before seen the disease.


Type 1 diabetes multiple sclerosis inflammation bowel disease and rheumatoidarthitis are all autoimmune diseases. In all cases, the immune system focuses on healthy tissues and not on the infective agents.


In the UK alone, around 4 million people have developed the condition, with some sufferers suffering from more than one. Globally, it's estimated that cases of autoimmune diseases are rising between 3% and 9% a year. Many scientists believe that environmental factors play a major factor in this growth.


Lee, who was formerly located at Cambridge University, stated that the human genetics haven't changed in the last couple of decades. There must be something outside that's responsible for our predisposition for autoimmune disease.


Vinuesa who was a former student at the Australian National University, supported this notion. She mentioned the shifts in food habits that took place as more countries adopted west-style diets and people ate more fast foods.


Vinuesa explained that a few essential components of fast food diets are not present which includes fiber. There is evidence to suggest that altering a person’s microbiome (the collection of microorganisms we have in our digestive system) can lead to a loss in certain body functions.


Changes in our microbiomes trigger autoimmune disease, of which over 100 have been identified.


The two scientists agreed that people have a higher risk of getting these diseases. They include celiac and lupus, which can trigger inflammation and swelling and lead to damage to various organs including the heart.


Vinuesa said, "If there is no genetic susceptibility, an autoimmune disorder will not always be a concern, regardless of how many Big Macs you eat." We can't do about the rapid expansion of fast food chains across the globe. Instead, our focus is in understanding the genetic mechanisms which cause autoimmune disorders and the reasons why certain people are more susceptible to the disease while others are not. We want to tackle the issue at the level of."


Modern technology allows us to spot tiny differences in DNA between large groups of people. This makes it possible to recognize common genetic patterns among people with an autoimmune disorder.


Lee stated that up until recent, we didn't have the tools necessary to identify DNA. Now, we have this amazing power and it has changed everything. We knew only about half dozen variations of DNA that could cause inflammation in the bowel when I began my research. Today, we have more than 250.


Lee and Vinuesa have been involved in this research since the beginning. Their research aims to understand the different types of diseases which doctors are currently studying and to discover the genetic mechanisms that lead to these diseases. When you examine immune-mediated diseases, such as the lupus disease - it's been discovered recently that there are numerous different variants of these diseases, which could be caused by various genetic pathways, said Vinuesa. This can make it challenging to determine the best treatment.


While there are a myriad of effective new therapies in development, we don't yet know the people they ought to be given to. This is due to the fact that we aren't able to pinpoint the precise nature of their illness. This is one of the major goals in research into autoimmune diseases. It is essential to understand how to classify and stratify patients so we can offer them the best treatment.


Lee explained that the increasing incidence of autoimmune diseases across the globe means that the development of new therapies and medicines is urgently needed more than ever before. At present, there are no cures to autoimmune diseases that typically develop in young people - while they're trying to complete their education, find their first job and have families, Lee said.


That means more people are likely to undergo surgery and/or have regular injections throughout their life. It's a bleak time for patients and a massive strain on health services. This is why we need to come up with innovative, efficient treatments.


Rheumatoid Arthritis is an autoimmune disease, meaning it's caused by the immune system attacking healthy tissue in the body. It's not yet known what causes it.


The antibodies that your immune system produces to fight viruses and bacteria are the ones you require to fight off infection.


If you suffer from Rheumatoid Arthritis, your immune system mistakenly sends antibodies to the lining of your joints, where they attack the tissue surrounding the joint.


The thin layer (synovium) that is a protective layer on your joints, can be inflamed and inflamed which releases chemicals and cause damage.


bones

Cartilage is the connective tissue that is stretchy and connects bones

Tendons are connective tissue that connects bone and muscles.

Ligaments - The ligaments - The tissue that connects cartilage to bone

If the problem isn't treated, it could result in the loss of alignment and form. Eventually, it can destroy the joint completely.


There have been a variety of theories as to why the immune response is a threat to joints. For instance the possibility of an infection could be the trigger. However , none of these theories has been proven.

Possible risk factors

You could be at greater risk for developing Click here rheumatoid arthritis If you don't take the steps listed below:


Your genes - There is some evidence suggesting that rheumatoid arthritis can be passed through families. But the chance of it passing to a child is not high because genes play only an important role in the condition.

hormones. Rheumatoid arthritis can be more prevalent in women than in men. This may be because of the impacts of the hormone oestrogen, though this has not been proven

Smoking is a Click here risk cause for rheumatoid artifiid. A few studies support this.